Acta Chemica Malaysia

Journal: Acta Chemica Malaysia (ACMY)
Author: Khadija Gillani, Saira Saeed, Syed M. Husnain, Surriya manzoor, Muhammad Rehan Hasan Shah Gilani, Naseem
Abbas, Faisal Shahzad
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2022.85.93

The delivery of drug has an incredible influence on treatment of chronic diseases. Various drugs are being used to treat such disease but are limited due to their side effects during their delivery to effective site. There is dire need to design such carrier molecules can cross blood–eye barrier, stay for long times, or mitigate side effects. By designing different drug carriers for site specific system for physiologically delivery of relevant concentration for long periods. By using cellular delivery systems, microelectromechanical (MEMs)-based devices, polymer matrices, or gene delivery systems, such issues can be solved. Stimulus-response polymers are gaining much attention of researcher for delivery of drug in a controlled way on specific sites of disease in human beings and to minimize deleterious effects and increase the frequency of drug. The polymer with novel combinations of monomers with stimuli responsive, biodegradable, and biocompatible can be synthesized. In current study, grafted polymers hydrogels were synthesized using acrylic acid, ethyl acrylate, hydroxy propyl methyl cellulose, benzoyl peroxide, and methylene bis-acrylamide to release the drug at the colon (pH=7). Hydrogels were characterized using various techniques FTIR-ATR, TGA, SEM, and XRD. Polymers were soft, transparent, foamy in touch, with high tensile strength, thermally stable till 300˚C and properly cross-linked. Swelling of hydrogels were observed at pH 1, 4, 7, 8, and 9.2, where optimum swelling was found at pH 7. The acrylic acid enhanced all Flory-Huggins solvent interaction parameters. The %age porosity and %age friction of sol-gel were measured as 91% and 35% respectively. The drug loading equilibrium was obtained in 3 hours. The kinetics of diclofenac potassium drug release were measured using Korsmeyer Peppas model and synthesized polymer showed maximum release (78-79%) at pH 7. Controlled release can easily be adjusted just by changing the percentage ratio of monomers used. Synthesized polymer is environment friendly, cost effective and easy to handle.

Journal: Acta Chemica Malaysia (ACMY)
Author: Irvan Adhin Cholilie, Yuni Kurniati, Tria Yusnita Utari, Willian Rahwanu
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.01.2022.31.34

Antioxidants have many different benefits in the body, including inhibiting the oxidation process. Antioxidants are found in several plants, including black sticky rice (Oryza sativa var glutinosa). Color pigment in black sticky rice contains a mixture of anthocyanin compounds that function as antioxidants and free radical scavengers. This study aims to describe the antioxidant activity of black glutinous rice extract with extraction for different hours and solvents. Research design is a literature study or a review of scientific articles. The antioxidant activity was tested using the DPPH method so that it could be applied as an innovative liquid soap with organic ingredients. The results obtained were that the stability of anthocyanins was influenced by pH, temperature, and extraction time, acetone solvent had a greater amount of anthocyanin extract than ethanol. Anthocyanins can be applied because they contain phenolic compounds in anthocyanins which can inhibit bacterial growth, marked by an inhibition zone.

Journal: Acta Chemica Malaysia (ACMY)
Author: Nworie, F. S, Ike-Amadi, A.C, Agha-Akpu J, Nworu, J
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2022.75.84

A one, two and three parametric equilibrium models as well as kinetic and mass transfer models were used to optimize the adsorption of cationic dye (methylene blue) onto a chemically modified biosorbent derived from plantain peels (PP) waste. The chemically modified PP was characterized using Braunauer-Emmett-Teller (BET), X-ray Diffraction (XRD), Fourier Transform Infra-red Spectroscopy (FTIR) and Scanning Electron Microscope (SEM). Parameters influencing adsorption were optimized and result indicated maximum adsorption at contact time of 120 S, pH of 8 and initial methylene blue (MTB) concentration of 7.75 × 10-6 mg/L. The maximum adsorption capacity was evaluated to be 222mmolkg-1. The data simulated into the equilibrium models based on error analysis and coefficient of non-determination indicated that the adsorption process followed mainly the Hill equilibrium isotherm model and perfectly fits the Elovic kinetics and mass transfer process as the rate determining step. The modified PP is recommended for the removal of cationic dyes in effluents and aqueous media.