IN-VITRO STUDY OF HYDROGEL FOR DICLOFENAC POTASSIUM RELEASE
Journal: Acta Chemica Malaysia (ACMY)
Author: Khadija Gillani, Saira Saeed, Syed M. Husnain, Surriya manzoor, Muhammad Rehan Hasan Shah Gilani, Naseem
Abbas, Faisal Shahzad
This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
The delivery of drug has an incredible influence on treatment of chronic diseases. Various drugs are being used to treat such disease but are limited due to their side effects during their delivery to effective site. There is dire need to design such carrier molecules can cross blood–eye barrier, stay for long times, or mitigate side effects. By designing different drug carriers for site specific system for physiologically delivery of relevant concentration for long periods. By using cellular delivery systems, microelectromechanical (MEMs)-based devices, polymer matrices, or gene delivery systems, such issues can be solved. Stimulus-response polymers are gaining much attention of researcher for delivery of drug in a controlled way on specific sites of disease in human beings and to minimize deleterious effects and increase the frequency of drug. The polymer with novel combinations of monomers with stimuli responsive, biodegradable, and biocompatible can be synthesized. In current study, grafted polymers hydrogels were synthesized using acrylic acid, ethyl acrylate, hydroxy propyl methyl cellulose, benzoyl peroxide, and methylene bis-acrylamide to release the drug at the colon (pH=7). Hydrogels were characterized using various techniques FTIR-ATR, TGA, SEM, and XRD. Polymers were soft, transparent, foamy in touch, with high tensile strength, thermally stable till 300˚C and properly cross-linked. Swelling of hydrogels were observed at pH 1, 4, 7, 8, and 9.2, where optimum swelling was found at pH 7. The acrylic acid enhanced all Flory-Huggins solvent interaction parameters. The %age porosity and %age friction of sol-gel were measured as 91% and 35% respectively. The drug loading equilibrium was obtained in 3 hours. The kinetics of diclofenac potassium drug release were measured using Korsmeyer Peppas model and synthesized polymer showed maximum release (78-79%) at pH 7. Controlled release can easily be adjusted just by changing the percentage ratio of monomers used. Synthesized polymer is environment friendly, cost effective and easy to handle.