Acta Chemica Malaysia

Journal: Acta Chemica Malaysia (ACMY)
Author: Deborah O. Momo, Osaro Iyekowa, Omonkhelin J Owolabi
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2025.87.93

The present study was aimed at investigating oil profile and the anti-inflammatory activity of methanol extract of the African weaver ant, Oeccophylla longinoda (OL) using three models in wistar rats. For the dextran, carrageenan and formaldehyde test models: 0.1 mL of 1.5% w/v dextran; 0.1 mL of carrageenan (1% w/v) and 0.2 mL of formaldehyde (1% w/v) were each injected into the sub plantar tissue of the hind paw of the rats respectively to induce inflammation while OL was administered orally at a dose of 200 and 400 mg/kg. Indomethacin (10 mg/kg) and Tween 80 (10 ml/kg) served as positive and negative standards respectively. The major components detected from the oil fraction were carvone (Retention time (Rt): area percent: 13.547: 21.12%) a terpenoid and oleic acid (32.273:7.16%), an unsaturated fatty acid. The extract showed a notable reduction in inflammation in each of the models, (𝑃 < 0.01) by decreasing the mean paw size of the rats after treatment in comparison to the negative control. The 200 and 400 mg extract in the three models showed significant inhibition of inflammation. These data suggest that OL had a positive anti-inflammatory effect on both acute and sub-chronic inflammation.

Journal: Acta Chemica Malaysia (ACMY)
Author: Dibie Nduka Edward and Dibie Chukwudumebi Esther
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2025.80.86

Aframomum sceptrum Seeds used as additives in many foods and enthnomedicinal remedies, are characterized by unstandardized postharvest handling methods. Additionally, their compositional chemistry are not fully investigated. Also, the influence of processing and storage on the compositional chemistry of Aframomum sceptrum Seeds are less investigated. This work investigated Aframomum sceptrum Seeds obtained from markets in Benin City, Edo State, for tannins, saponins, cyanogenic glycosides, alkaloids, thiamine, riboflavin, Potassium (K), Calcium (Ca), Magnesium (Mg), Chromium (Cr) and Selenium (Se). The influence of sun drying, grinding and storage in the open laboratory and at water activities (aw) of 0.23, 0.52, and 0.92, on the examined parameters were also determined. All investigations were carried out in accordance with standard methods. In raw Aframomum sceptrum Seeds the results were cyanogenic glycosides (0.18±0.04mg/g); saponins (8.174±1.21mg/g); tannins (2.81±0.62mg/g); alkaloids (2.92±0.35mg/g); thiamine (9.980±0.305ppm); riboflavin (0.625±0.031ppm). The range of values obtained for the mineral elements were K (3,850±10.968 – 4,915.783±15.912) mg/kg; Ca (316.677±11.189 – 386.106±5.520) mg/kg; Mg (221.843±5.691 – 253.903±21.004) mg/kg; Cr (1.257±0.045 – 1.457±0.416) mg/kg and Se (0.303±0.017 – 0.421±0.089) mg/kg. Processing and storage positively influenced the values of the phytochemicals, but resulted in decrease in thiamine and riboflavin. Statistically, the reported storage changes in phytochemicals were at P<0.05 significant. Additionally, at P<0.05 the decreases in thiamine and riboflavin were statistically significant. These findings would be relevant in the formulation of standard methods for the handling of Aframomum sceptrum Seeds.

Journal: Acta Chemica Malaysia (ACMY)
Author: Dhikik Dhoka Guring, Bijay Mahato, Bikal Poudel
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2025.77.79

Hibiscus sabdariffa (Zobo), widely consumed in Nigeria for its nutritional and medicinal value, is known for its antioxidant and therapeutic properties. This study investigated the effects of aqueous Hibiscus sabdariffa(Zobo) extract on kidney and liver function, as well as body weight, in adult Wistar rats. Twenty-four adult Wistar rats were divided into four groups (n=6). Group A served as control, while Groups B, C, and D received1 mg/kg, 2 mg/kg, and 3 mg/kg of Zobo extract, respectively, for 14 days. Body weights were recorded before and after treatment. Blood samples were collected post-sacrifice for kidney and liver function analysis. Significant weight gain was observed in the control (50.00 ± 9.50 g), 1 mg/kg (46.33 ± 3.23 g), and 3 mg/kg(40.67 ± 7.69 g) groups, while the 2 mg/kg group showed the least gain (26.00 ± 5.77 g). Elevated AST and reduced ALP levels were noted in treated groups, indicating possible hepatocellular stress. Urea level sincreased in 1 mg/kg and 2 mg/kg groups, while creatinine decreased in the 2 mg/kg group. Zobo extract influenced body weight and induced dose-dependent alterations in hepatic and renal biomarkers, suggesting both therapeutic and potential toxicological effects.