APPLICATION OF CO3(BTC)2∙12H2O AS A METAL-ORGANIC FRAMEWORK IN CONTROLLED UPTAKE-RELEASE OF OXALIPLATIN
Journal: Acta Chemica Malaysia (ACMY)
Author: Hassan Keypour, Jamal Kouhdareh, Sedigheh Alavinia, Ammar Maryamabadi
This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Metal-organic frameworks (MOFs) are a class of Coordination polymer of metal ions or clusters coordinated to organic ligands to form which has nanometer cavities. In the category porous materials, they have domination of great surface areas, tunable pore size and structure, tunable combination and functionalized surface area and porous size, ability to encapsulate and post-synthesis which enables them unique advantages important point concerning the possible use of such functional materials for applications in adsorption and release of drug and active pharmaceutical ingredient. By examining the patterns resulting from N2 adsorption/desorption isotherms and thermogravimetric analysis, it is possible to understand the thermal stability and the appropriate volume of holes available to the molecule for the presence of guest molecules. In this report, we study uptake and release properties of Oxaliplatin from nano Co (II)-MOF in comparison with bulk Co(II)-MOF. To explore the absorption ability of the Co (II)-MOF to Oxaliplatin, a fresh sample of Co-BTC metal-organic framework was immersed in an aqueous solution of Oxaliplatin and was
monitored in real-time with HPLC spectroscopy. Results show that the adsorbed quantity of Oxaliplatin over Nano Co-BTC metal-organic framework is much higher than those over a bulk Co-BTC. According to the Oxaliplatin adsorption times, the time is 22 h, the uptake of Oxaliplatin (99.94%) on Nano Co-BTC is remarkable and clarity exceeds that of bulk Co-BTC and activated carbon in the aqueous solution of Oxaliplatin. When these interactions disappear with increasing Oxaliplatin extrusion, labor in the second stage is largely governed by a free-diffusion process, and full Oxaliplatin release from Nano Co-BTC takes more than 5 days to reach equilibrium.