Organotin (IV) based Rabeprazole and Pregabalin Complexes Formation and Biocidal Investigation

Journal: Acta Chemica Malaysia (ACMY)
Author: Muhammad Tariq, Ahmad Kaleem Qureshi, Muhammad Hamid, Naseem Abbas, Ajaz Hussain and Muhammad Naeem Khan

ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: https://doi.org/10.2478/acmy-2020-0003

New organotin (IV) complexes with NaL1 (sodium salt of 2-[[4-(3-methoxy-propoxy) 3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide) and NaL2 (sodium salt of 3- aminomethyl-5-methylhexanoic acid) were synthesized by the reaction of diorganotin (IV) and triorganotin (IV) salt (Bu3SnCl, Ph3SnCl, Bu2SnCl2, Me2SnCl2) using the solvent (dry toluene) by constant stirring and refluxing. All the organotin (IV) complexes were characterized by different diagnostic techniques such as FT-IR (Infra-red) and UV-visible spectroscopy. The results exhibited that ligand NaL1 (sodium salt) is attached to tin metal by a nitrogen atom of benzimidazole ring and the oxygen atom of the sulfonyl group. While ligand NaL2 (sodium salt) coordinate with tin(IV) moiety through oxygen atom of the carboxylate group. The newly synthesized complexes 1 & 2 of ligand NaL1 (sodium salt) showed trigonal bipyramidal geometry while complexes 3 & 4 octahedral geometry around tin(IV) centre. The organotin(IV) complexes 5-7 of ligand NaL2 (sodium salt) have the tetrahedral geometry around tin(IV) centre. The synthesized complexes (1-7) were tested for antifungal and antibacterial microbial activities. All the complexes showed significant antibacterial and anti-fungal activities against tested bacterial and fungal strains.