Weed infestation is a significant factor contributing to low wheat yields, particularly in developing regionslike Nepal. This study evaluates the efficacy of various chemical herbicides in controlling weeds and theirimpact on wheat yield in Dang District during the 2022-2023 growing season. Eight treatments were tested,including weedy, weed-free, and various herbicide combinations, using a Randomized Complete Block Design(RCBD) with three replications. Results indicated that chemical treatments significantly affected weeddiversity, plant height, grain yield, and economic returns. The combination of Metribuzin + 2, 4-D showed thelowest weed diversity and highest grain yield (2.31 t/ha), while Sulfosulfuron + 2, 4-D yielded the highest netreturn (14.71 thousand Rs/ha) and B:C ratio (1:1.19). These findings underscore the importance of effectiveweed management strategies in enhancing wheat production and ensuring food security in Nepal.