GC-MS ANALYSIS AND EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF THE OIL FRACTION OF METHANOL EXTRACT OF OECOPHYLLA LONGINODA (WEAVER ANT) IN WISTAR RATS

Journal: Acta Chemica Malaysia (ACMY)
Author: Deborah O. Momo, Osaro Iyekowa, Omonkhelin J Owolabi
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2025.45.51

The present study was aimed at investigating oil profile and the anti-inflammatory activity of methanol extract of the African weaver ant, Oeccophylla longinoda (OL) using three models in wistar rats. For the dextran, carrageenan and formaldehyde test models: 0.1 mL of 1.5% w/v dextran; 0.1 mL of carrageenan (1% w/v) and 0.2 mL of formaldehyde (1% w/v) were each injected into the sub plantar tissue of the hind paw of the rats respectively to induce inflammation while OL was administered orally at a dose of 200 and 400 mg/kg. Indomethacin (10 mg/kg) and Tween 80 (10 ml/kg) served as positive and negative standards respectively. The major components detected from the oil fraction were carvone (Retention time (Rt): area percent: 13.547: 21.12%) a terpenoid and oleic acid (32.273:7.16%), an unsaturated fatty acid. The extract showed a notable reduction in inflammation in each of the models, (𝑃 < 0.01) by decreasing the mean paw size of the rats after treatment in comparison to the negative control. The 200 and 400 mg extract in the three models showed significant inhibition of inflammation. These data suggest that OL had a positive anti-inflammatory effect on both acute and sub-chronic inflammation.