DOSE-DEPENDENT EFFECTS OF AQUEOUS Hibiscus sabdariffa (ZOBO) EXTRACT ON HEPATORENAL FUNCTION IN ADULT WISTAR RATS

Journal: Acta Chemica Malaysia (ACMY)
Author: Dhikik Dhoka Guring, Bijay Mahato, Bikal Poudel
ISSN: 2576-6732
e-ISSN: 2576-6724

This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.26480/acmy.02.2025.35.37

Hibiscus sabdariffa (Zobo), widely consumed in Nigeria for its nutritional and medicinal value, is known for its antioxidant and therapeutic properties. This study investigated the effects of aqueous Hibiscus sabdariffa(Zobo) extract on kidney and liver function, as well as body weight, in adult Wistar rats. Twenty-four adult Wistar rats were divided into four groups (n=6). Group A served as control, while Groups B, C, and D received1 mg/kg, 2 mg/kg, and 3 mg/kg of Zobo extract, respectively, for 14 days. Body weights were recorded before and after treatment. Blood samples were collected post-sacrifice for kidney and liver function analysis. Significant weight gain was observed in the control (50.00 ± 9.50 g), 1 mg/kg (46.33 ± 3.23 g), and 3 mg/kg(40.67 ± 7.69 g) groups, while the 2 mg/kg group showed the least gain (26.00 ± 5.77 g). Elevated AST and reduced ALP levels were noted in treated groups, indicating possible hepatocellular stress. Urea level sincreased in 1 mg/kg and 2 mg/kg groups, while creatinine decreased in the 2 mg/kg group. Zobo extract influenced body weight and induced dose-dependent alterations in hepatic and renal biomarkers, suggesting both therapeutic and potential toxicological effects.