DEVELOPMENT OF UV-SPECTROSCOPY METHOD FOR DETERMINATION OF HYDROQUINONE & CLOBETASOL IN SKIN -LIGHTENING CREAMS IN ADEN, YEMEN
Journal: Acta Chemica Malaysia (ACMY)
Author: Wafa F. S. Badulla, Ebtesam S. Bamahmood, Randa M. Saif
This is an open access journal distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Skin whitening creams & products (SL) contain certain unsafe chemicals such as mercury, steroids such as; Clobetasol propionate, and hydroquinone (HQ), which have negative effects on health if used excessively. The present study aimed to determine the presence of the HQ and CP in the SL creams that are sold in the Aden Market and measure the pH of these creams as well. The determination of the HQ & CP in the SL creams was carried out by using UV-Spectroscopy. This study indicated the presence of HQ in all creams in the range between 3.00 ± 1.08- 6.72 ± 0.02 except in Cream I. The lower % was found in Cream V and the higher % was in Cream II. The CP was detected in five creams out of seven creams. The range of the CP was between 0.0085 ± 0.46 – and 0.164 ± 0.15. The pH of all formulations was found to be between 3.63 ± 0.006 and 7.50 ± 0.02. The SL creams or products may contain HQ and CP even if the label doesn’t indicate the presence of these compounds. There should be more control, restriction of the use, and distribution of such products to prevent possible long-term adverse effects.